Abhishek Kumar
pharmacy
November 2021
A controlled porosity osmotic pump of cellulose acetate for osmotic delivery of Gliclazide has been developed and the influence of different pore-forming agents and osmotic agents on in vitro drug release was investigated. The capsule membrane was prepared by the phase inversion technique. To ensure the osmotic delivery, two approaches were adopted: (i) PEG-400 was used in different concentrations as a pore-forming agent (ii) the drug was encapsulated with osmogent sodium chloride to increase the osmotic pressure. Formulations were evaluated for weight variation, thickness, void volume, tensile strength, and in-situ pore formation. Dye test revealed in-situ pore formation in the membrane.A 32 factorial design was employed to optimize the concentration of pore forming agent (X1) and osmogent (X2) as independent variables. Both the selected independent variables had a significant influence on the amount of drugs released. The transformed values of the independent and dependent variables were subjected to multiple linear regression analysis to establish a full-model second-order polynomial equation. The coefficient of independent variables suggests that osmogent Sodium chloride is the major contributing factor for the amount of drug released (b1>b2). A contour plot is presented to represent the effect of independent variables on the amount of drugs released. A checkpoint batch was also prepared to prove the validity of the mathematical model. Optimization studies showed asymmetric membrane capsule with 70% PEG as pore-forming agent and 1.5% of sodium chloride as osmogent as the best formulation. The release kinetics reveal that the optimized batch fits well with the Zero-order model.
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© Airo Journals 2021
