Kartik Mishra
science
December 2021
Self-assembly is a potent method for building supramolecular materials for a wide range of applications, including energy harvesting and biomedicine. Enzyme-instructed self-assembly (EISA) is a method for creating supramolecular materials for biomedical purposes that has various advantages. The advantages and unique features of EISA in the preparation of biofunctional supramolecular nanomaterials and hydrogels from peptides are highlighted in this paper. In situ molecular self-assembly can be triggered by EISA. As a result, supramolecular structures can be created in situ using overexpression enzymes in disease locations to improve therapeutic selectivity and efficacy. The precursor may be used in the EISA process, which is a two-component self-assembly procedure. The precursor may aid in the stabilisation of EISA-formed hydrophobic peptide nanostructures. More crucially, the outcome of molecular self-assembly may be determined by the precursor EISA has recently been shown to be able to kinetically control peptide folding and shape, as well as the cellular absorption behaviour of supramolecular nanomaterials. Researchers can produce supramolecular nonmaterial in a more precise way and sometimes under spatiotemporal control using a mix of various methods to initiate molecular self-assembly. EISA is a potent and unique technology for making supramolecular biofunctional materials that can't be made any other way.
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© Airo Journals 2021
