Nishant Parween
Chemistry
May 2022
Mefenamic acid, sometimes known as Mama, is a commonly used NSAID for sedation. Due to Mama's low water solvency and other factors, The normal negative effects of NSAIDs are also present. The purpose of this research was to improve the water solubility of Mama in order to boost its bioavailability and impact digestion. Solid dispersions of Mama were made by employing polyethylene glycol 6000 and varying types (stearate, D-1670, palmitate, P-1670, and laurate, D-1216) and amounts of sucrose esters as transporters. The absence of precious stones from Mama is confirmed by the X-ray diffraction results. Based on the results of disintegration tests conducted on fake gastric juice, the component containing 10% D-1216 significantly increased water solvency. Despite the dissolution difference, Mama showed a high apparent penetrability coefficient across human Caco-2 digestive epithelial cell layers, and the addition of chemicals did not increase drug entrance...
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