Rakesh Dayaram Tiwle
Pharmacy
September 2024
The aim of the current research work was to prepare and optimise fast-dissolving tablets of ondansetron HCl by the incorporation of different ratios of MCC with lactose. Tablets were prepared by using the direct pressure method in which Ac-Di-Sol and magnesium stearate were incorporated. A two-factor, three-level full factorial design accompanied by response surface methodology (RSM) was used to study the effect of the concentration of MCC and Ac-Di-Sol on the hardness of the tablet and the disintegration time. Optimized formulation was analyzed, which passed all the specifications as desired and showed improved characteristics of tablets, thus providing insight for the formulation of effective fast-dissolving drug delivery systems
742- 753
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