Sandhaya Sharma
Pharmacology
April 2025
The present study investigates the pharmacological action of aqueous Syzygium cumini (Jamun) extract by employing in vivo and in vitro models. The work is to analyze its antihyperglycemic, antidyslipidemic, anti-inflammatory, antioxidant, and anticancer properties. Results showed that high-dose extract (400 mg/kg) significantly reduced blood glucose levels to a level equivalent to Metformin in rats with STZ-induced diabetes, indicating the presence of hypoglycemic action. It showed anti-inflammatory effects on carrageenan-induced paw oedema and substantial lipid-lowering effects on rats with hyperlipidaemia caused by a high-fat diet. The compound's radical scavenging and reducing properties were demonstrated in in vitro antioxidant studies employing DPPH, ABTS, and FRAP. Moreover, the IC₌₀ value was less than 100 µg/mL, and its cytotoxicity against the MCF-7 and HeLa cancer cell lines was dose-dependent. These findings highlight the therapeutic potential of Syzygium cumini in the management of metabolic disorders and as a lead for bioactive compounds of potential drug interest.
116- 134
© Airo Journals 2021
