Parveena Jan
Histopathology
October 2025
This study investigated the effectiveness of Hematoxylin and Eosin (H&E) staining in the histopathological evaluation of upper gastrointestinal lesions obtained through endoscopic gastric biopsies. A total of 100 biopsy specimens were analyzed to assess staining quality, diagnostic clarity, and clinical relevance. The results revealed that chronic gastritis was the most common diagnosis (40%), followed by gastric ulcers (20%), precancerous lesions (15%), and gastric carcinoma (18%). H&E staining provided excellent nuclear and cytoplasmic differentiation in 70% of cases, with adequate staining quality in another 20%, ensuring reliable morphological assessment. Definitive diagnoses facilitating clear clinical management were achieved in 85% of specimens, while 10% required additional special stains or molecular testing, and 5% remained inconclusive due to technical limitations. These findings underscore the pivotal role of H&E staining as a cost-effective, reliable, and essential diagnostic tool in gastrointestinal pathology, while highlighting the need for standardized staining protocols to enhance diagnostic accuracy.
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© Airo Journals 2021
